Structural highlights
Function
REPS2_HUMAN Involved in growth factor signaling through its influence on the Ral signaling pathway.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The solution structure of the Eps15 homology (EH) domain of a human POB1 (partner of RaIBP1) has been determined by uniform 13C/15N labeling and heteronuclear multidimensional nuclear magnetic resonance spectroscopy. The POB1 EH domain consists of two EF-hand structures, and the second one binds a calcium ion. In the calcium-bound state, the orientation of the fourth alpha-helix relative to the other helices of the POB1 EH domain is slightly different from that of calbindin, and much more different from those of calmodulin and troponin C, on the basis of their atomic coordinates.
Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1).,Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:9928989[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S. Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1). FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:9928989
