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1hyj
From Proteopedia
| 1hyj, 20 NMR models () | |||||||||
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| Ligands: | |||||||||
| Domains: | FYVE | ||||||||
| Related: | 1hyi | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN
The recruitment of trafficking and signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediated by FYVE domains. Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles. The multistep binding mechanism involved nonspecific insertion of a hydrophobic loop into the lipid bilayer, positioning and activating the binding pocket. Ligation of PtdIns(3)P then induced a global structural change, drawing the protein termini over the bound phosphoinositide by extension of a hinge. Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines.
Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1HYJ is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Kutateladze T, Overduin M. Structural mechanism of endosome docking by the FYVE domain. Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696 doi:10.1126/science.291.5509.1793
Page seeded by OCA on Mon Feb 16 17:36:24 2009
