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1hrp
From Proteopedia
| 1hrp, resolution 3.00Å () | |||||||||
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| Sites: | , , , , and | ||||||||
| Ligands: | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN
The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.
Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1HRP is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW. Crystal structure of human chorionic gonadotropin. Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136 doi:10.1038/369455a0
Page seeded by OCA on Mon Sep 21 19:39:17 2009
