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1hdr
From Proteopedia
| 1hdr, resolution 2.50Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | CDNA (Homo sapiens) | ||||||||
| Activity: | 6,7-dihydropteridine reductase, with EC number 1.5.1.34 | ||||||||
| Domains: | PRK12828, PRK08220 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
A human dihydropteridine reductase (EC 1.6.99.10) has been created from a rat cDNA clone by a single five-oligonucleotide mutagenesis reaction and expressed in good yield in Escherichia coli. The enzyme has been purified to homogeneity, and kinetic identity to the naturally occurring enzyme has been proven. Crystallization has also been achieved, and the crystal structure was solved using 2.5 A data that was refined to an R value of 16.9%. The structure described in this report represents the first complete structural characterization of this important human enzyme.
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue., Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, Whiteley JM, J Biol Chem. 1993 Dec 25;268(36):26836-41. PMID:8262916
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1HDR is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, Whiteley JM. The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue. J Biol Chem. 1993 Dec 25;268(36):26836-41. PMID:8262916
Page seeded by OCA on Tue Feb 17 05:26:16 2009
