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1h6k
From Proteopedia
NUCLEAR CAP BINDING COMPLEX
The heterodimeric nuclear cap binding complex (CBC) binds to 5'-capped polymerase II transcripts. It enhances the efficiency of several mRNA maturation steps and is essential for U snRNA nuclear export in multicellular eukaryotes. The 2A crystal structure of human CBC shows that the large subunit, CBP80, comprises three domains, each containing consecutive helical hairpins and resembling the so-called MIF4G domain found in several other proteins involved in RNA metabolism. The small subunit, CPB20, has an RNP fold and associates with the second and third domains of CBP80. Site-directed mutagenesis revealed 4 residues of CBP20 which are critical for cap binding. A model for cap binding is proposed based on these results and the known mode of binding of RNA to RNP domains.
Crystal structure of the human nuclear cap binding complex., Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S, Mol Cell. 2001 Aug;8(2):383-96. PMID:11545740
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1H6K is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S. Crystal structure of the human nuclear cap binding complex. Mol Cell. 2001 Aug;8(2):383-96. PMID:11545740
Page seeded by OCA on Mon Feb 16 18:40:27 2009
