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1h4l

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1h4l, resolution 2.65Å ()

Domains:

S_TKc, S_TKc, CDK5_activator

Structural annotation:
Resources:	CATH : 1H4La02, 1H4La01, 1H4Lb01, 1H4Lb02, 1H4Ld00, 1H4Le00 InterPro : Ipr008271, Ipr011009, Ipr000719, Ipr002290, Ipr013763, Ipr004944, Ipr011028 Pfam : PF00069, PF03261 SCOP : d1h4la_, d1h4lb_, d1h4ld_, d1h4le_ UniProt : Q00535, Q15078

Functional annotation:
Resources:	GeneCard : CDK5, CDK5R1
Cellular component:	nucleus dendrite growth cone cell soma neuromuscular junction lamellipodium cell projection membrane cytosol axon cytoplasm filopodium dendritic spine cyclin-dependent protein kinase 5 activator complex contractile fiber
Biological process:	neuron differentiation cell migration embryonic development axonogenesis neurite development cell division cell proliferation protein amino acid phosphorylation regulation of cell migration positive regulation of neuron apoptosis cell cycle cell-matrix adhesion neuron migration ionotropic glutamate receptor signaling pathway brain development neuron adhesion regulation of cyclin-dependent protein kinase activity axon guidance regulation of neuron differentiation axonal fasciculation acetylcholine receptor signaling, muscarinic pathway
Molecular function:	ErbB-3 class receptor binding cyclin-dependent protein kinase activity ATP binding nucleotide binding transferase activity protein binding ErbB-2 class receptor binding protein kinase activity acetylcholine receptor activator activity kinase activity tau-protein kinase activity protein serine/threonine kinase activity cadherin binding calcium ion binding cyclin-dependent protein kinase 5 activator activity protein serine/threonine kinase activator activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX

Publication Abstract from PubMed

CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator. Despite its partial structural similarity with the cyclins, p25 displays an unprecedented mechanism for the regulation of a cyclin-dependent kinase. p25 tethers the unphosphorylated T loop of CDK5 in the active conformation. Residue Ser159, equivalent to Thr160 on CDK2, contributes to the specificity of the CDK5-p35 interaction. Its substitution with threonine prevents p35 binding, while the presence of alanine affects neither binding nor kinase activity. Finally, we provide evidence that the CDK5-p25 complex employs a distinct mechanism from the phospho-CDK2-cyclin A complex to establish substrate specificity.

Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:11583627

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1H4L is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A. Structure and regulation of the CDK5-p25(nck5a) complex. Mol Cell. 2001 Sep;8(3):657-69. PMID:11583627

Page seeded by OCA on Mon Feb 16 13:04:15 2009

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1h4l

From Proteopedia

STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX

About this Structure

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