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1gux
From Proteopedia
RB POCKET BOUND TO E7 LXCXE MOTIF
The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7., Lee JO, Russo AA, Pavletich NP, Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1GUX is a 3 chains structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.
Reference
- Lee JO, Russo AA, Pavletich NP. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340 doi:10.1038/36038
Page seeded by OCA on Mon Feb 16 14:09:11 2009
