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1gnh
From Proteopedia
| 1gnh, resolution 3.00Å () | |||||||||
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| Ligands: | |||||||||
| Domains: | PTX | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
HUMAN C-REACTIVE PROTEIN
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.
Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:8599761
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1GNH is a 10 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ. Three dimensional structure of human C-reactive protein. Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:8599761
Page seeded by OCA on Tue Feb 17 05:12:10 2009
