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1ghq

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1ghq, resolution 2.04Å ()
Ligands: ,
Domains: complement_C3_C4_C5, A2M_comp, CCP
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CR2-C3D COMPLEX STRUCTURE

Publication Abstract from PubMed

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1GHQ is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS. Structure of complement receptor 2 in complex with its C3d ligand. Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479 doi:10.1126/science.1059118

Page seeded by OCA on Mon Feb 16 15:37:29 2009

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