1g4d

Structural highlights

Function

REPC_BPMU Promotes latency by binding operators O1 and O2 in the enhancer/operator region, thereby repressing the transcription from the Pe (early) promoter and blocking the expression of the genes required for replication (lytic growth). Competes with DDE-recombinase A for binding to the internal activation sequence (IAS), which overlaps O1 and O2. The outcome of this competition determines if the virus enters latency or starts replication. Makes the cell immune to superinfection by repressing genes expression of any subsequent incoming viral genome.^{[1] [2] [3] [4] [5]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Ranquet C, Geiselmann J, Toussaint A. The tRNA function of SsrA contributes to controlling repression of bacteriophage Mu prophage. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10220-5. PMID:11517307 doi:10.1073/pnas.171620598
2. ↑ O'Handley D, Nakai H. Derepression of bacteriophage mu transposition functions by truncated forms of the immunity repressor. J Mol Biol. 2002 Sep 13;322(2):311-24. PMID:12217693 doi:10.1016/s0022-2836(02)00755-6
3. ↑ Ranquet C, Toussaint A, de Jong H, Maenhaut-Michel G, Geiselmann J. Control of bacteriophage mu lysogenic repression. J Mol Biol. 2005 Oct 14;353(1):186-95. PMID:16154589 doi:10.1016/j.jmb.2005.08.015
4. ↑ Marshall-Batty KR, Nakai H. Activation of a dormant ClpX recognition motif of bacteriophage Mu repressor by inducing high local flexibility. J Biol Chem. 2008 Apr 4;283(14):9060-70. PMID:18230617 doi:10.1074/jbc.M705508200
5. ↑ Kahmeyer-Gabbe M, Howe MM. Regulatory factors acting at the bacteriophage Mu middle promoter. J Bacteriol. 1996 Mar;178(6):1585-92. PMID:8626285 doi:10.1128/jb.178.6.1585-1592.1996