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1g3j

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1g3j, resolution 2.10Å ()

Domains:

ARM, ARM, CTNNB1_binding

Structural annotation:
Resources:	CATH : 1G3Ja00, 1G3Jb00, 1G3Jc00, 1G3Jd00 InterPro : Ipr013284, Ipr000225, Ipr000357, Ipr011989, Ipr009071, Ipr000910, Ipr013558 Pfam : PF00514, PF02985, PF08347 SCOP : d1g3ja_, d1g3jb_, d1g3jc_, d1g3jd_ UniProt : P35222, P70062

Functional annotation:
Resources:	GeneCard : CTNNB1
Cellular component:	adherens junction Z disc cytoplasm transcription factor complex intercellular junction cytoskeleton nucleus membrane cell-cell adherens junction basolateral plasma membrane microvillus membrane apical part of cell beta-catenin destruction complex plasma membrane lateral plasma membrane fascia adherens membrane fraction lamellipodium
Biological process:	embryonic arm morphogenesis epithelial to mesenchymal transition synaptic vesicle transport positive regulation of epithelial cell differentiation skeletal development positive regulation of osteoblast differentiation negative regulation of osteoclast differentiation proximal/distal pattern formation dorsal/ventral pattern formation regulation of transcription, DNA-dependent negative regulation of cell differentiation cellular process positive regulation of transcription from RNA polymerase II promoter bone resorption cell maturation Wnt receptor signaling pathway cellular morphogenesis during differentiation regulation of osteoblast differentiation embryonic digit morphogenesis forebrain development cell differentiation ectoderm development hemopoiesis endoderm formation regulation of cell proliferation regulation of transcription cell fate determination negative regulation of transcription from RNA polymerase II promoter dorsal/ventral axis specification androgen receptor signaling pathway Wnt receptor signaling pathway through beta-catenin positive regulation of transcription transcription heart development regulation of cell differentiation morphogenesis of embryonic epithelium lung development synapse organization and biogenesis cell-cell adhesion endodermal cell fate commitment cell fate specification positive regulation of transcription, DNA-dependent osteoclast differentiation patterning of blood vessels camera-type eye morphogenesis odontogenesis of dentine-containing teeth embryonic hindlimb morphogenesis pancreas development synaptic transmission cell adhesion negative regulation of transcription, DNA-dependent multicellular organismal development
Molecular function:	chromatin binding structural molecule activity transcription coactivator activity signal transducer activity binding protein C-terminus binding transcription factor activity androgen receptor binding alpha-catenin binding protein binding cadherin binding DNA binding sequence-specific DNA binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX

Publication Abstract from PubMed

The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.

Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1G3J is a 4 chains structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Graham TA, Weaver C, Mao F, Kimelman D, Xu W. Crystal structure of a beta-catenin/Tcf complex. Cell. 2000 Dec 8;103(6):885-96. PMID:11136974

Page seeded by OCA on Tue Feb 17 14:38:44 2009

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1g3j

From Proteopedia

CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX

About this Structure

Reference

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