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1g0u
From Proteopedia
| 1g0u, resolution 2.40Å () | |||||||||
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| Sites: | , , , , , , , , , , , , , , , , , , and | ||||||||
| Ligands: | |||||||||
| Activity: | Proteasome endopeptidase complex, with EC number 3.4.25.1 | ||||||||
| Related: | 1ryp | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE
The core particle (CP) of the yeast proteasome is composed of four heptameric rings of subunits arranged in a hollow, barrel-like structure. We report that the CP is autoinhibited by the N-terminal tails of the outer (alpha) ring subunits. Crystallographic analysis showed that deletion of the tail of the alpha 3-subunit opens a channel into the proteolytically active interior chamber of the CP, thus derepressing peptide hydrolysis. In the latent state of the particle, the tails prevent substrate entry by imposing topological closure on the CP. Inhibition by the alpha-subunit tails is relieved upon binding of the regulatory particle to the CP to form the proteasome holoenzyme.
A gated channel into the proteasome core particle., Groll M, Bajorek M, Kohler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D, Nat Struct Biol. 2000 Nov;7(11):1062-7. PMID:11062564
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1g0u is a 28 chain structure of Proteasome with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
See Also
Reference
- Groll M, Bajorek M, Kohler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D. A gated channel into the proteasome core particle. Nat Struct Biol. 2000 Nov;7(11):1062-7. PMID:11062564 doi:10.1038/80992
