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1f3h

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1f3h, resolution 2.58Å ()

Ligands:

Domains:

BIR

Structural annotation:
Resources:	CATH : 1F3Ha00, 1F3Hb00 InterPro : Ipr001370 Pfam : PF00653 SCOP : d1f3ha_, d1f3hb_ UniProt : O15392

Functional annotation:
Resources:	GeneCard : BIRC5
Cellular component:	cytosol interphase microtubule organizing center cytoplasmic microtubule midbody chromosome nucleus protein complex spindle microtubule cytoplasm intracellular centriole chromosome, pericentric region
Biological process:	G2/M transition of mitotic cell cycle apoptosis positive regulation of exit from mitosis establishment of chromosome localization anti-apoptosis cell cycle positive regulation of mitotic cell cycle mitosis cytokinesis cell division spindle checkpoint negative regulation of caspase activity protein complex localization
Molecular function:	caspase inhibitor activity zinc ion binding metal ion binding cysteine protease inhibitor activity protein heterodimerization activity microtubule binding endopeptidase inhibitor activity identical protein binding protein homodimerization activity tubulin binding protein binding cofactor binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN

Publication Abstract from PubMed

Survivin is a 16.5 kDa protein that is expressed during the G2/M phase of the cell cycle and is hypothesized to inhibit a default apoptotic cascade initiated in mitosis. This inhibitory function is coupled to survivin's localization to the mitotic spindle. To begin to address the structural basis of survivin's function, we report the X-ray crystal structure of a recombinant form of full length survivin to 2.58 A resolution. Survivin consists of two defined domains including an N-terminal Zn2+-binding BIR domain linked to a 65 A amphipathic C-terminal alpha-helix. The crystal structure reveals an extensive dimerization interface along a hydrophobic surface on the BIR domain of each survivin monomer. A basic patch acting as a sulfate/phosphate-binding module, an acidic cluster projecting off the BIR domain, and a solvent-accessible hydrophobic surface residing on the C-terminal amphipathic helix, are suggestive of functional protein-protein interaction surfaces.

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement., Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP, Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:10876248

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1F3H is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:10876248 doi:10.1038/76838

Page seeded by OCA on Mon Feb 16 10:34:00 2009

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1f3h

From Proteopedia

X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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