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1f31
From Proteopedia
| 1f31, resolution 2.60Å () | |||||||||
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| Sites: | |||||||||
| Ligands: | , | ||||||||
| Non-Standard Residues: | , , | ||||||||
| Activity: | Bontoxilysin, with EC number 3.4.24.69 | ||||||||
| Domains: | Toxin_R_bind_C, Toxin_trans, Peptidase_M27, Toxin_R_bind_N | ||||||||
| Related: | 1epw | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH A TRISACCHARIDE
Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1F31 is a 1 chain structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
Reference
- Swaminathan S, Eswaramoorthy S. Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B. Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256
Page seeded by OCA on Mon Feb 16 16:41:46 2009
