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1eik

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1eik, 10 NMR models ()
Activity: DNA-directed RNA polymerase, with EC number 2.7.7.6
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml



Contents

Solution Structure of RNA Polymerase Subunit RPB5 from Methanobacterium Thermoautotrophicum

Publication Abstract from PubMed

RPB5 is an essential subunit of eukaryotic and archaeal RNA polymerases. It is a proposed target for transcription activator proteins in eukaryotes, but the mechanism of interaction is not known. We have determined the solution structure of the RPB5 subunit from the thermophilic archeon, Methanobacterium thermoautotrophicum. MtRBP5 contains a four-stranded beta-sheet platform supporting two alpha-helices, one on each side of the beta-sheet, resulting in an overall mushroom shape that does not appear to have any structural homologues in the structural database. The position and conservation of charged surface residues suggests possible modes of interaction with other proteins, as well as a rationale for the thermal stability of this protein.

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum., Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH, Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6311-5. PMID:10841538

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1eik is a 1 chain structure with sequence from Methanothermobacter thermautotrophicus. Full experimental information is available from OCA.

See Also

Reference

  • Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH. Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6311-5. PMID:10841538
  • Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, Kennedy MA, Davidson AR, Pai EF, Gerstein M, Edwards AM, Arrowsmith CH. Structural proteomics of an archaeon. Nat Struct Biol. 2000 Oct;7(10):903-9. PMID:11017201 doi:http://dx.doi.org/10.1038/82823

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