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From Proteopedia

1ebv, resolution 3.20Å ()
Ligands:	, ,
Non-Standard Residues:
Activity:	Prostaglandin-endoperoxide synthase, with EC number 1.14.99.1
Structural annotation: Resources: CATH : 1Ebva02, 1Ebva01 InterPro : Ipr002007, Ipr000742, Ipr013032, Ipr010255, Ipr006210, Ipr006209 Pfam : PF03098, PF00008 SCOP : d1ebva1, d1ebva2 UniProt : P05979
Functional annotation: Cellular component: cytoplasm endoplasmic reticulum integral to membrane microsome nucleus membrane Biological process: response to oxidative stress prostaglandin biosynthetic process lipid biosynthetic process fatty acid biosynthetic process electron transport regulation of blood pressure Molecular function: prostaglandin-endoperoxide synthase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen metal ion binding peroxidase activity heme binding iron ion binding
Evolutionary conservation: Toggle Conservation Colors: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID

About this Structure

1ebv is a 1 chain structure with sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

• Loll PJ, Sharkey CT, O'Connor SJ, Dooley CM, O'Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions. Mol Pharmacol. 2001 Dec;60(6):1407-13. PMID:11723249