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1dzi
From Proteopedia
| 1dzi, resolution 2.10Å () | |||||||||
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| Ligands: | , | ||||||||
| Non-Standard Residues: | |||||||||
| Domains: | vWA_integrins_alpha_subunit | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX
We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.
Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:10778855
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1DZI is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC. Structural basis of collagen recognition by integrin alpha2beta1. Cell. 2000 Mar 31;101(1):47-56. PMID:10778855 doi:10.1016/S0092-8674(00)80622-4
Page seeded by OCA on Mon Feb 16 22:21:34 2009
