1dtx

Structural highlights

Function

VKTHA_DENAN Serine protease inhibitor homolog that blocks voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.6/KCNA6) (IC(50)=0.4-150 nM) and facilitates neurotransmitter release.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Dendrotoxin

References

1. ↑ Harvey AL. Twenty years of dendrotoxins. Toxicon. 2001 Jan;39(1):15-26. PMID:10936620
2. ↑ Mourao CB, Schwartz EF. Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals. Mar Drugs. 2013 Jun 14;11(6):2069-112. doi: 10.3390/md11062069. PMID:23771044 doi:http://dx.doi.org/10.3390/md11062069