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1dt7

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1dt7, 40 NMR models ()

Ligands:

Domains:

S-100B, S-100A13

Structural annotation:
Resources:	CATH : 1Dt7A00, 1Dt7B00 InterPro : Ipr013787, Ipr011992, Ipr001751, Ipr002048, Ipr002117, Ipr013872, Ipr010991, Ipr011615, Ipr008967, Ipr012346, Ipr015551 Pfam : PF00036, PF01023 SCOP : d1dt7a_, d1dt7b_, d1dt7x_, d1dt7y_ UniProt : P04631, P04637

Functional annotation:
Cellular component:	cytoplasm nucleus endoplasmic reticulum nuclear matrix nucleolus nucleoplasm insoluble fraction mitochondrion
Biological process:	learning and/or memory regulation of transcription, DNA-dependent negative regulation of helicase activity induction of apoptosis by intracellular signals negative regulation of cell cycle caspase activation via cytochrome c DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis response to DNA damage stimulus base-excision repair protein tetramerization multicellular organismal development protein complex assembly cell aging cell differentiation ER overload response nucleotide-excision repair protein localization transcription cellular response to glucose starvation apoptosis cell cycle arrest regulation of apoptosis cell proliferation negative regulation of cell growth cell cycle regulation of mitochondrial membrane permeability
Molecular function:	tau protein binding zinc ion binding metal ion binding calcium ion binding DNA strand annealing activity transcription factor activity protein heterodimerization activity protein binding enzyme binding DNA binding nuclease activity protein N-terminus binding ATP binding copper ion binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

Publication Abstract from PubMed

A Ca2+ dependent conformational change in dimeric S100B(betabeta) is required for it to bind p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain. A peptide derived from this region of p53 (residues 367-388) was found to have no regular structure in its native form by NMR spectroscopy, but becomes helical when bound to Ca2+ loaded S100B(betabeta). The three-dimensional structure of this complex reveals several favorable hydrophobic and electrostatic interactions between S100B(betabeta) and the p53 peptide in the binding pocket, where S100B(betabeta) sterically blocks sites of phosphorylation and acetylation on p53 that are important for transcription activation.

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)., Rustandi RR, Baldisseri DM, Weber DJ, Nat Struct Biol. 2000 Jul;7(7):570-4. PMID:10876243

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1DT7 is a 4 chains structure of sequences from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Rustandi RR, Baldisseri DM, Weber DJ. Structure of the negative regulatory domain of p53 bound to S100B(betabeta). Nat Struct Biol. 2000 Jul;7(7):570-4. PMID:10876243 doi:10.1038/76797

Page seeded by OCA on Mon Feb 16 12:16:27 2009

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1dt7

From Proteopedia

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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