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1d3i
From Proteopedia
CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY
Two human rhinovirus serotypes complexed with two- and five-domain soluble fragments of the cellular receptor, intercellular adhesion molecule-1, have been investigated by X-ray crystallographic analyses of the individual components and by cryo-electron microscopy of the complexes. The three-dimensional image reconstructions provide a molecular envelope within which the crystal structures of the viruses and the receptor fragments can be positioned with accuracy. The N-terminal domain of the receptor binds to the rhinovirus 'canyon' surrounding the icosahedral 5-fold axes. Fitting of molecular models into the image reconstruction density identified the residues on the virus that interact with those on the receptor surface, demonstrating complementarity of the electrostatic patterns for the tip of the N-terminal receptor domain and the floor of the canyon. The complexes seen in the image reconstructions probably represent the first stage of a multistep binding process. A mechanism is proposed for the subsequent viral uncoating process.
Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor., Kolatkar PR, Bella J, Olson NH, Bator CM, Baker TS, Rossmann MG, EMBO J. 1999 Nov 15;18(22):6249-59. PMID:10562537
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1D3I is a 5 chains structure of sequences from Homo sapiens and Human rhinovirus sp.. Full crystallographic information is available from OCA.
Reference
- Kolatkar PR, Bella J, Olson NH, Bator CM, Baker TS, Rossmann MG. Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor. EMBO J. 1999 Nov 15;18(22):6249-59. PMID:10562537 doi:10.1093/emboj/18.22.6249
Page seeded by OCA on Tue Feb 17 13:47:21 2009
Categories: Homo sapiens | Human rhinovirus sp. | Bella, J. | Rossmann, M G. | Common cold | Cryo-electron microscopy | Fitting of x-ray structures into cryo-em reconstruction | Hrv14 | Human rhinovirus | Icam-1 | Icosahedral virus | Rhinovirus-receptor complex | Virus uncoating | Virus/ viral protein
