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1d2m
From Proteopedia
| 1d2m, resolution 1.90Å () | |||||||||
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| Ligands: | , | ||||||||
| Domains: | PRK05298, UVR, HELICc, DEXHc | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME
In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:10578047
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1D2M is a 1 chain structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
- Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S. Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair. J Biochem. 1999 Dec;126(6):986-90. PMID:10578047
Page seeded by OCA on Tue Feb 17 05:56:27 2009
