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1buy
From Proteopedia
| 1buy, 1 NMR models () | |||||||||
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| Domains: | EPO_TPO | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE
The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1BUY is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS. NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743 doi:10.1038/2302
Page seeded by OCA on Mon Feb 16 22:25:11 2009
