First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

1bqh

From Proteopedia

Jump to: navigation, search

1bqh, resolution 2.80Å ()

Sites:

, , and

Ligands:

Structural annotation:
Resources:	CATH : 1Bqha02, 1Bqha01, 1Bqhb00, 1Bqhd01, 1Bqhd02, 1Bqhe00, 1Bqhg00, 1Bqhh00, 1Bqhi00, 1Bqhk00 InterPro : Ipr001039, Ipr011162, Ipr003597, Ipr013783, Ipr011161, Ipr003006, Ipr007110, Ipr010579, Ipr015707, Ipr015468, Ipr013151, Ipr003599 Pfam : PF00129, PF07654, PF00047 SCOP : d1bqha1, d1bqha2, d1bqhb_, d1bqhd2, d1bqhd1, d1bqhe_, d1bqhg_, d1bqhh_, d1bqhi_, d1bqhk_ UniProt : P01901, P01887, P01731

Functional annotation:
Cellular component:	MHC class I protein complex integral to membrane membrane external side of plasma membrane extracellular space integral to plasma membrane cell surface
Biological process:	immune response antigen processing and presentation defense response antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of endogenous antigen antigen processing and presentation of peptide antigen via MHC class I cellular defense response cytotoxic T cell differentiation T cell mediated immunity positive regulation of calcium-mediated signaling cell surface receptor linked signal transduction
Molecular function:	protein binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1 MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8
2 About this Structure
3 See Also
4 Reference

MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8

Publication Abstract from PubMed

The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb., Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH, Immunity. 1998 Oct;9(4):519-30. PMID:9806638

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1bqh is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998 Oct;9(4):519-30. PMID:9806638

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://www.proteopedia.org/wiki/index.php/1bqh"

1bqh

From Proteopedia

Contents

MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8

About this Structure

See Also

Reference

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

random

Search

Toolbox