First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
1bke
From Proteopedia
| 1bke, resolution 3.15Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||||
| Domains: | ALBUMIN | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID
Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs. Despite intensive efforts, the detailed structural basis of fatty acid binding to HSA has remained elusive. We have now determined the crystal structure of HSA complexed with five molecules of myristate at 2.5 A resolution. The fatty acid molecules bind in long, hydrophobic pockets capped by polar side chains, many of which are basic. These pockets are distributed asymmetrically throughout the HSA molecule, despite its symmetrical repeating domain structure.
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites., Curry S, Mandelkow H, Brick P, Franks N, Nat Struct Biol. 1998 Sep;5(9):827-35. PMID:9731778
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1BKE is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Curry S, Mandelkow H, Brick P, Franks N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 1998 Sep;5(9):827-35. PMID:9731778 doi:10.1038/1869
Page seeded by OCA on Wed Feb 18 08:19:05 2009
