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1axc

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1axc, resolution 2.60Å ()

Domains:

PCNA, PRK01115

Structural annotation:
Resources:	InterPro : Ipr000730, Ipr003175 Pfam : PF00705, PF02747 SCOP : d1axca2, d1axca1, d1axcc2, d1axcc1, d1axce1, d1axce2 UniProt : P12004, P38936

Functional annotation:
Resources:	GeneCard : PCNA, CDKN1A
Cellular component:	cyclin-dependent protein kinase holoenzyme complex nuclear lamina PCNA complex nucleus replication fork DNA replication factor C complex cytoplasm cytosol
Biological process:	DNA repair base-excision repair, gap-filling intracellular protein transport phosphoinositide-mediated signaling DNA replication regulation of DNA replication cell proliferation negative regulation of cyclin-dependent protein kinase activity response to UV cell cycle arrest cell cycle regulation of cyclin-dependent protein kinase activity negative regulation of cell proliferation positive regulation of non-apoptotic programmed cell death induction of apoptosis by intracellular signals positive regulation of B cell proliferation negative regulation of apoptosis response to DNA damage stimulus
Molecular function:	MutLalpha complex binding DNA polymerase processivity factor activity DNA binding protein binding zinc ion binding metal ion binding cyclin-dependent protein kinase inhibitor activity protein kinase inhibitor activity cyclin binding protein kinase activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

HUMAN PCNA

Publication Abstract from PubMed

The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA., Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J, Cell. 1996 Oct 18;87(2):297-306. PMID:8861913

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1AXC is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell. 1996 Oct 18;87(2):297-306. PMID:8861913

Page seeded by OCA on Mon Feb 16 18:33:11 2009

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1axc

From Proteopedia

HUMAN PCNA

About this Structure

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