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1a58

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1a58, resolution 1.95Å ()
Gene: CYCLOPHILIN (Brugia malayi)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

CYCLOPHILIN FROM BRUGIA MALAYI

Publication Abstract from PubMed

A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.

The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1a58 is a 1 chain structure with sequence from Brugia malayi. Full crystallographic information is available from OCA.

See Also

Reference

  • Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD. The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680

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